Rogue Amoeba’s Jeff Johnson takes on a new security feature of Sierra, Gatekeeper Path Randomization:
We support Apple’s efforts to increase security for all users on MacOS. However, this specific change will have a great deal of negative impact, while providing no security gain for the vast majority of apps. Users will be stuck with apps that don’t work (or update) as expected. The simple change we’ve proposed would still provide Apple with the desired security benefits, while removing the downside this will cause for users. We hope you’ll duplicate our radar, and encourage you to test your software on 10.12 for possible problems.
I’d heard about this during WWDC, but Jeff does a nice job of laying out why sometimes security measures cause more problems than they actually end up solving.